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The van Opijnen Lab


LATEST NEWS

November 2018 - We have a wonderful new paper accepted at PLOS Pathogens describing a super cool genomics approach to map the entire transcriptional landscape of S. pneumoniae TIGR4. This work is a collaborative effort with the Meyer lab with Indu Warrier as first shared author!

November 2018 - Collaboration between six people in the lab resulted in a new paper under review describing a pan-genomic perspective on the emergence, maintenance and predictability of antibiotic resistance!

November 2018 - If you are interested in joining the Lab as a graduate student, either on the computational or wet bench side then don't hesitate to inquire about the possibilities. Or apply to BC right now!

October 2018 - Interested in donating to BC and thereby support the research that we perform or just curious about what drives us everyday? Watch the video at the bottom of this page to get inspired :)!

October 2018 - Fluoroquinolones like ciprofloxacin and A. baumannii don’t go together well. Why? Well, it’s all about resistance...as usual, but also about prophage induction, which is unusual. There are ways around this resistance though, which you can read all about in our newest paper that’s already available at the bioRxiv while it’s also under review!

September 2018 - Our AMR-SysBio team had a fantastic meeting in San Diego, talking about the accomplishments from the last year, and the plans for the coming one. Curious about who was there? Well, go and see for yourself here…

August 2018 - If you know a little bit about our lab it will be no surprise that we like Tn-Seq. Hey, it was invented by the PI, so what's not to like about it?! Anyway, we have something new...we combined Tn-Seq with microfluidics, developing droplet Tn-Seq or dTn-Seq. "Why?" you ask. Well, now we can entangle single-cell phenotypes, but also interactions between bacteria and or host cells and there are many other possibilities. Go check it out on bioRxiv while it's under review!

July 2018 - Ever wondered whether adaptive evolution is predictable? Well, we believe it is through multi-omics data integration, network analyses and machine learning! Moreover, we can now predict whether a bacterium will survive in its environment and overcome the stress it is facing. These are critical steps if we ever want to move towards personalized infectious disease treatments, instead of one-size fits all solutions, which are feeding the current increase in unsuccessful treatments and the rise in antibiotic resistance. Read all about it on the bioRxiv while it's under review!

June 2018 - We are all excited to have Sophie Bodrog officially join the lab as a technician and Suyen Espinoza has joined the lab as a graduate student!

May 2018 - The lab will be presenting 6 posters at the Boston Bacterial Meeting later this month and an oral presentation by Karen Zhu on our latest experimental and predictive modeling work! Wow!

May 2018 - Defne Surujon officially passed her 'qualifyers' and is now super officially on her way towards a PhD in the BC grad program.

May 2018 - We are excited and sad at the same time to say congrats and goodbye to 5 of our best graduating senior lab members ever: Symren Dhaliwal, Lauren Havens, Camille Homa, Allison Chowdhury and Sophie Bodrog!

April 2018 - We contributed some work to an amazing new piece of work by our collaborator Jianmin Gao from BC Chemistry. Just published in the Journal of the American Chemical Society a new rapid and high-throughput phage-display screen for peptides that recognize antibiotic resistant bacteria!

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The van Opijnen Lab


LATEST NEWS

November 2018 - We have a wonderful new paper accepted at PLOS Pathogens describing a super cool genomics approach to map the entire transcriptional landscape of S. pneumoniae TIGR4. This work is a collaborative effort with the Meyer lab with Indu Warrier as first shared author!

November 2018 - Collaboration between six people in the lab resulted in a new paper under review describing a pan-genomic perspective on the emergence, maintenance and predictability of antibiotic resistance!

November 2018 - If you are interested in joining the Lab as a graduate student, either on the computational or wet bench side then don't hesitate to inquire about the possibilities. Or apply to BC right now!

October 2018 - Interested in donating to BC and thereby support the research that we perform or just curious about what drives us everyday? Watch the video at the bottom of this page to get inspired :)!

October 2018 - Fluoroquinolones like ciprofloxacin and A. baumannii don’t go together well. Why? Well, it’s all about resistance...as usual, but also about prophage induction, which is unusual. There are ways around this resistance though, which you can read all about in our newest paper that’s already available at the bioRxiv while it’s also under review!

September 2018 - Our AMR-SysBio team had a fantastic meeting in San Diego, talking about the accomplishments from the last year, and the plans for the coming one. Curious about who was there? Well, go and see for yourself here…

August 2018 - If you know a little bit about our lab it will be no surprise that we like Tn-Seq. Hey, it was invented by the PI, so what's not to like about it?! Anyway, we have something new...we combined Tn-Seq with microfluidics, developing droplet Tn-Seq or dTn-Seq. "Why?" you ask. Well, now we can entangle single-cell phenotypes, but also interactions between bacteria and or host cells and there are many other possibilities. Go check it out on bioRxiv while it's under review!

July 2018 - Ever wondered whether adaptive evolution is predictable? Well, we believe it is through multi-omics data integration, network analyses and machine learning! Moreover, we can now predict whether a bacterium will survive in its environment and overcome the stress it is facing. These are critical steps if we ever want to move towards personalized infectious disease treatments, instead of one-size fits all solutions, which are feeding the current increase in unsuccessful treatments and the rise in antibiotic resistance. Read all about it on the bioRxiv while it's under review!

June 2018 - We are all excited to have Sophie Bodrog officially join the lab as a technician and Suyen Espinoza has joined the lab as a graduate student!

May 2018 - The lab will be presenting 6 posters at the Boston Bacterial Meeting later this month and an oral presentation by Karen Zhu on our latest experimental and predictive modeling work! Wow!

May 2018 - Defne Surujon officially passed her 'qualifyers' and is now super officially on her way towards a PhD in the BC grad program.

May 2018 - We are excited and sad at the same time to say congrats and goodbye to 5 of our best graduating senior lab members ever: Symren Dhaliwal, Lauren Havens, Camille Homa, Allison Chowdhury and Sophie Bodrog!

April 2018 - We contributed some work to an amazing new piece of work by our collaborator Jianmin Gao from BC Chemistry. Just published in the Journal of the American Chemical Society a new rapid and high-throughput phage-display screen for peptides that recognize antibiotic resistant bacteria!

The van Opijnen Lab practices microbial systems biology which basically means that we try to understand a bacterium as a complete system. So instead of carefully studying the organism one component at the time we build networks of all the genetic elements that drive a bacterium's behavior. Thereby we rapidly develop a real good understanding of how a bacterium does its thing, for instance trigger disease.

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Our work


We mainly focus on pathogenic bacteria and apply a combination of high-throughput robotics, next generation sequencing and computational biology to discover what makes them tick.

Our work


We mainly focus on pathogenic bacteria and apply a combination of high-throughput robotics, next generation sequencing and computational biology to discover what makes them tick.

The van Opijnen Lab focuses on projects to determine how bacteria trigger disease on a genome-wide level and species-wide scale, we elucidate the fine inner workings of antibiotics and we develop new genome-wide tools and screens to identify novel antimicrobial compounds.

More research

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The Lab


The Lab


Tim van opijnen

Principal Investigator

Dr. van Opijnen received his Masters in evolutionary genetics from the University of Amsterdam, and as a graduate student he worked on the evolution of HIV at the Medical School of the University of Amsterdam. As a postdoctoral fellow in the lab of Dr. Andrew Camilli at Tufts University in Boston his interests shifted to bacterial pathogens and systems biology. In January 2013 he started his own lab on Microbial Systems Biology at Boston College.

The workers

Postdocs & Grad students

Check out the PEOPLE for more information on who's who in the lab. If you are interested in joining the lab as a postdoc, grad student or technician, check-out the JOBS page for possible openings.

 

The Rookies

Undergraduates

We house a large flock of undergraduate students on the computational and wet-bench side of the lab. Each undergraduate works in close collaboration with a postdoc or graduate student. If you are interested in joining the lab as an undergraduate student please send an inquiry email including your CV to Dr. van Opijnen.

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