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The van Opijnen Lab


LATEST NEWS

May 2018 - The lab will be presenting 6 posters at the Boston Bacterial Meeting later this month and an oral presentation by Karen Zhu on our latest experimental and predictive modeling work! Wow!

April 2018 - We contributed some work to an amazing new piece of work by our collaborator Jianmin Gao from BC Chemistry. Just published in the Journal of the American Chemical Society a new rapid and high-throughput phage-display screen for peptides that recognize antibiotic resistant bacteria!

March 2018 - Our latest entry on the bioRxiv describes a super cool genomics approach to map the entire transcriptional landscape of S. pneumoniae. This work is a collaborative effort with the Meyer lab with Indu Warrier as first shared author!

March 2018 - Interested in donating to BC and thereby support the research that we perform or just curious about what drives us everyday? Watch the video at the bottom of this page to get inspired :)!

February 2018 - If you are interested in joining the Lab as a graduate student, either on the computational or wet bench side then don't hesitate to inquire about the possibilities.

January 2018 - Happy New Year! Lots of great work is going on in the van Opijnen Lab and we anticipate 2018 to be a fantastic year science wise. Stay tuned for multiple upcoming publications focusing on new approaches and some very exciting findings. Besides that, we expect new graduate students to join the lab and some graduate students will have to pass there qualifying exam this spring!

November 2017 - Lauren Havens, one of our top-undergraduates in the news with a great interview about life and her work in the lab.

September 2017 - The Biology Department is looking for the next Tenure Track Assistant professor in Microbial Systems/Synthetic Biology. You can find more info at: www.bc.edu/biology or apply at apply.interfolio.com/45021

August 2017 - Karen and Paul publish the first metabolic model for Streptococcus pneumoniae in Cell Reports! Their work shows how integration of genome-wide data with topological network analysis reveals how a bacterium responds to stress. Surprisingly, they show that different transcriptional and phenotypic response networks exist in bacteria and how this undermines the widely held assumption that genes that change in expression upon an environmental disturbance must also phenotypically matter. Find the article in Cell Reports and an accompanying news article here.

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The van Opijnen Lab


LATEST NEWS

May 2018 - The lab will be presenting 6 posters at the Boston Bacterial Meeting later this month and an oral presentation by Karen Zhu on our latest experimental and predictive modeling work! Wow!

April 2018 - We contributed some work to an amazing new piece of work by our collaborator Jianmin Gao from BC Chemistry. Just published in the Journal of the American Chemical Society a new rapid and high-throughput phage-display screen for peptides that recognize antibiotic resistant bacteria!

March 2018 - Our latest entry on the bioRxiv describes a super cool genomics approach to map the entire transcriptional landscape of S. pneumoniae. This work is a collaborative effort with the Meyer lab with Indu Warrier as first shared author!

March 2018 - Interested in donating to BC and thereby support the research that we perform or just curious about what drives us everyday? Watch the video at the bottom of this page to get inspired :)!

February 2018 - If you are interested in joining the Lab as a graduate student, either on the computational or wet bench side then don't hesitate to inquire about the possibilities.

January 2018 - Happy New Year! Lots of great work is going on in the van Opijnen Lab and we anticipate 2018 to be a fantastic year science wise. Stay tuned for multiple upcoming publications focusing on new approaches and some very exciting findings. Besides that, we expect new graduate students to join the lab and some graduate students will have to pass there qualifying exam this spring!

November 2017 - Lauren Havens, one of our top-undergraduates in the news with a great interview about life and her work in the lab.

September 2017 - The Biology Department is looking for the next Tenure Track Assistant professor in Microbial Systems/Synthetic Biology. You can find more info at: www.bc.edu/biology or apply at apply.interfolio.com/45021

August 2017 - Karen and Paul publish the first metabolic model for Streptococcus pneumoniae in Cell Reports! Their work shows how integration of genome-wide data with topological network analysis reveals how a bacterium responds to stress. Surprisingly, they show that different transcriptional and phenotypic response networks exist in bacteria and how this undermines the widely held assumption that genes that change in expression upon an environmental disturbance must also phenotypically matter. Find the article in Cell Reports and an accompanying news article here.

The van Opijnen Lab practices microbial systems biology which basically means that we try to understand a bacterium as a complete system. So instead of carefully studying the organism one component at the time we build networks of all the genetic elements that drive a bacterium's behavior. Thereby we rapidly develop a real good understanding of how a bacterium does its thing, for instance trigger disease.

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Our work


We mainly focus on pathogenic bacteria and apply a combination of high-throughput robotics, next generation sequencing and computational biology to discover what makes them tick.

Our work


We mainly focus on pathogenic bacteria and apply a combination of high-throughput robotics, next generation sequencing and computational biology to discover what makes them tick.

The van Opijnen Lab focuses on projects to determine how bacteria trigger disease on a genome-wide level and species-wide scale, we elucidate the fine inner workings of antibiotics and we develop new genome-wide tools and screens to identify novel antimicrobial compounds.

More research

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The Lab


The Lab


Tim van opijnen

Principal Investigator

Dr. van Opijnen received his Masters in evolutionary genetics from the University of Amsterdam, and as a graduate student he worked on the evolution of HIV at the Medical School of the University of Amsterdam. As a postdoctoral fellow in the lab of Dr. Andrew Camilli at Tufts University in Boston his interests shifted to bacterial pathogens and systems biology. In January 2013 he started his own lab on Microbial Systems Biology at Boston College.

The workers

Postdocs & Grad students

Check out the PEOPLE for more information on who's who in the lab. If you are interested in joining the lab as a postdoc, grad student or technician, check-out the JOBS page for possible openings.

 

The Rookies

Undergraduates

We house a large flock of undergraduate students on the computational and wet-bench side of the lab. Each undergraduate works in close collaboration with a postdoc or graduate student. If you are interested in joining the lab as an undergraduate student please send an inquiry email including your CV to Dr. van Opijnen.

A production of Boston College