Arch Pharm Res. 2017 Jul 22. doi: 10.1007/s12272-017-0933-y. [Epub ahead of print]

Pneumonia and Streptococcus pneumoniae vaccine.

Kim GL1, Seon SH1, Rhee DK2.

Author information

Abstract

Pneumonia is an inflammatory disease of the lung, responsible for high morbidity and mortality worldwide. It is caused by bacteria, viruses, fungi, or other microorganisms. Streptococcus pneumoniae, a gram-positive bacterium with over 90 serotypes, is the most common causative agent. Moreover, comorbid factors including heart failure, renal disease, and pulmonary disease could increase the risk of pneumococcal pneumonia. Since the advent of the pneumococcal vaccine in the 1980s, the incidence of pneumonia has decreased significantly. However, current vaccines confer only limited protection against serotypes included in the vaccine. Thus, to overcome this limitation, new types of pneumococcal vaccines have been sought and under clinical trials. In this review, we discuss pneumonia and summarize the various types of pneumococcal vaccines in progress.

KEYWORDS:

Pneumococcal vaccine; Pneumonia; Streptococcus pneumoniae

PMID: 28735461 DOI: 10.1007/s12272-017-0933-y