Antimicrob Agents Chemother. 2017 Jun 19. pii: AAC.00478-17. doi: 10.1128/AAC.00478-17. [Epub ahead of print]

Genome Evolution to Penicillin Resistance in Serotype 3 Streptococcus pneumoniae by Capsular Switching.

Chiba N1,2, Murayama SY3, Morozumi M1, Iwata S1, Ubukata K4.

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Abstract

Streptococcus pneumoniae of serotype 3 was collected from cases of invasive pneumococcal disease (n = 124) throughout Japan from April 2010 to March 2013. A penicillin-resistant S. pneumoniae (PRSP) isolate from an adult patient, KK0981 of serotype 3, was identified among these strains. Whole-genome analysis characterized this PRSP as a recombinant strain derived from PRSP of serotype 23F with the cps-locus (20.3 kb) replaced by that of a penicillin-susceptible strain of serotype 3.

Copyright © 2017 American Society for Microbiology.

PMID: 28630198 DOI: 10.1128/AAC.00478-17