Carbohydr Res. 2017 Mar 14;443-444:29-36. doi: 10.1016/j.carres.2017.03.012. [Epub ahead of print]
Carbohydrate mimics have been studied for a long time as useful sugar substitutes, both in the investigation of biological events and in the treatment of sugar-related diseases. Here we report further evaluation of the capabilities of inositols as carbohydrate substitutes. The conformational features of an inositol-model of a simplified repeating unit corresponding to the capsular polysaccharide of Streptococcus pneumoniae 19F has been evaluated by computational analysis, and compared to the native repeating unit. The inositol mimic was synthesized, and its experimental spectroscopic data allowed for verification of the theoretical results.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Carbohydrate mimic; Inositol; Streptococcus pneumoniae; Vaccine
PMID: 28324771 DOI: 10.1016/j.carres.2017.03.012