Front Microbiol. 2017 Feb 20;8:224. doi: 10.3389/fmicb.2017.00224. eCollection 2017.

Role of Streptococcus pneumoniae Proteins in Evasion of Complement-Mediated Immunity.

Andre GO1, Converso TR2, Politano WR1, Ferraz LF1, Ribeiro ML3, Leite LC4, Darrieux M1.

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The complement system plays a central role in immune defense against Streptococcus pneumoniae. In order to evade complement attack, pneumococci have evolved a number of mechanisms that limit complement mediated opsonization and subsequent phagocytosis. This review focuses on the strategies employed by pneumococci to circumvent complement mediated immunity, both in vitro and in vivo. At last, since many of the proteins involved in interactions with complement components are vaccine candidates in different stages of validation, we explore the use of these antigens alone or in combination, as potential vaccine approaches that aim at elimination or drastic reduction in the ability of this bacterium to evade complement.


Streptococcus pneumoniae; complement system; pneumococcal moonlighting proteins; protein-based vaccines; virulence factors pneumococcal surface proteins

PMID: 28265264 PMCID: PMC5316553 DOI: 10.3389/fmicb.2017.00224