Int J Infect Dis. 2015 Dec 7. pii: S1201-9712(15)00282-9. doi: 10.1016/j.ijid.2015.12.001. [Epub ahead of print]

Streptococcus pneumoniae AS CAUSE OF INFECTION IN INFANTS LESS THAN 60 DAYS OF AGE: SEROTYPES AND ANTIMICROBIAL SUSCEPTIBILITY.

Soto-Noguerón A1, Carnalla-Barajas MN1, Solórzano-Santos F2, Arrendondo-García JL3, Arzate-Barbosa P3, Tinoco-Favila JC4, Anzurez-Gutiérrez A5, Echániz-Aviles G6.

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Abstract

OBJECTIVE:

The aim of this study was to determine the distribution of serotypes and the antimicrobial susceptibilities of Streptococcus pneumoniae clinical isolates causing invasive and noninvasive disease in children ≤ 60 days of age in hospitals in Mexico.

METHODS:

A 15-year retrospective study was conducted during the period from 2000 to 2014. Pneumococcal clinical isolates were serotyped by the Quellung reaction, and antimicrobial susceptibility testing was performed with the broth microdilution method.

RESULTS:

A total of 126 pneumococcal isolates were collected. Pneumonia was the most frequent diagnosis (40.5%) followed by meningitis (29.4%), septicemia (16.7%) and other clinical entities, including otitis media and conjunctivitis (13.5%). The most frequent serotypes before the introduction of PCV7 were 19F, 23F, 7F and 35B. Serotypes 3, 6A, 10A, 12F and 15A/B increased after the introduction of PCV7. Serotype 19A was isolated most frequently in the pneumonia and meningitis cases only after the introduction of PCV7, and it displayed a high resistance to penicillin.

CONCLUSIONS:

Although the number of infections in infants less than 60 days of age was low, such infections were not unusual events. New vaccination strategies should be evaluated to limit the risks in this age group.

Copyright © 2015. Published by Elsevier Ltd.

KEYWORDS:

Streptococcus pneumoniae; antimicrobial susceptibility; invasive pneumococcal diseases; newborns; pneumococcal vaccines; serotypes

PMID: 26673859 [PubMed - as supplied by publisher]