J Pak Med Assoc. 2015 Oct;65(10):1122-4.

Cryptococcus neoformans and Streptococcus pneumoniae co-infection in post-traumatic meningitis in a patient with unknown HIV status.

Saleem F1, Fasih N1, Zafar A1.

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Meningitis is a serious disease associated with considerable morbidity and mortality. Mixed meningeal infections due to bacteria and fungi are exceptionally rare. Here we report a case of meningeal co-infection with cryptococcus neoformans and streptococcus pneumoniae in a patient with unknown human immunodeficiency virus status. Because of the rarity of such cases, stringent screening of every cerebrospinal fluid specimen to exclude the presence of multiple pathogens is imperative. Assessment of patients for immunodeficiencies in case of isolation of an opportunistic organism like cryptococcus is also needed.


Cryptococcosis, Meningeal co-infections, Cryptococcal meningitis, Post-traumatic meningitis.

PMID: 26440847 [PubMed - in process]